Hello there. I am having a difficult time getting CellProfiler to work on my Mac. It is 10.8, so I should be within the parameters.
Can you give us some more information? Any errors, or warnings, or crash? You can look in Console for the event (e.g. CellProfiler crash) and post the results here. Did it ever work?
You can also try removing the CellProfiler preferences as described here: viewtopic.php?f=14&t=806#p6248
and then try again.