Currently, we have both PC and Macs available in the Imaging Platform. I am usually a PC-person, but found that since Macs can handle more memory, it tends to run better on very high resolution images. Really, though, if you are saving images as a lossless format (PNG or TIF, NOT JPG) at a reasonable size, you shouldn’t have any issues, nor should you need a full 8GB of RAM. Since you will be running these cycles locally and not on a cluster, you may want to have the 4GB of RAM. There is a chance that even if you have ~96 or more image sets with several figure windows open, CellProfiler will crash. Once you have your pipeline completely setup, I would run the entire cycle without any figure windows displayed. You can modify this setting in your Preferences (File >>Preferences).