Keck Foundation-sponsored Job opportunity

The Wyss Institute of Harvard University and the Department of Biology at the
University of Virginia seek outstanding applicants for two interdisciplinary Postdoctoral
fellowships in functional genomics and 3D systems biology. The candidates will lead the
development of new technologies to create the first single-cell resolution model of
animal metabolism using Caenorhabditis elegans.

In the last 25 years, genomic tools have dramatically accelerated the pace of data
generation. However, our understanding of how biological systems work has not grown
nearly as fast. This project aims to develop and integrate C. elegans functional
genomics, in animal RNAseq (FISSEQ), and whole animal single-cell resolution
modeling tools to develop the first model of animal metabolism. There are currently no
models that can fully represent animal life with its complex levels of organization, from
genes, to cells, to organs. Without such models it is not possible to completely
anticipate the effects of drugs on different organ systems, to design tissues or organs
our bodies would not reject, or simply to understand life at the molecular level. Through
the generous support of the Keck Foundation and the PEW Charitable Trust, and your
leadership, we will open new doors in biology and biomedicine.

Specific goals include optimizing and performing high-content genome-wide reverse
genetics screens for fat regulators, or developing FISSEQ in whole C. elegans.
The candidate must have an extraordinary motivation to learn and succeed as an
independent scientist. A PhD in life sciences by the appointment start date is required.
Productivity documented with peer-reviewed first author publications is required.
Effective oral and written communication skills are required. Experience in at least one
of the following is preferred but not required: C. elegans research and/or RNAseq (both
library construction and data analysis), high-end microscopy (high-resolution or highthroughput)
and/or bioinformatics and biological scripting languages (Matlab,
Python/Biophyton). No previous post-doctoral experience is preferred.

Apply through Jobs@ Uva ( Attach: a one-page personal
statement describing your scientific accomplishments and your interests, curriculum
vitae, and contact information (including phone numbers) of three references who might
be contacted for recommendations.
Search for posting number 0618980.

Review of applications will begin November 3, 2016; however, the position will remain
open until filled.

Questions regarding the research should be directed to: Eyleen O’Rourke
ejo8b@Virginia.EDU. Questions about the Candidate Profile process or Jobs@UVA
should be directed to: Rich Haverstrom

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