Detection of Cell Patches in Cell Profiler


I’m new CellProfiler user and new member of this blog. Is it possible to detect cell patches in CellProfiler? Imagine we have 1000 cells randomly distributed in a square but 100 cells have been colonized somewhere among them. I would appreciate if someone gives me a hint if it’s possible to detect such an structure in CP. I’ve attached a schematic illustration of my cells here:



You can try to smooth or morph the image first, to make these patches become single dense objects, and perform segmentation after.

As shown here:

and here: