Data lost after saving

Dear all,
There is a really weird thing when I analysis MGX data. They are all lost after saving. It is just as below. Anyone has faced this kind of problem?

Is that a network drive by any chance?

Best to copy the files local, process them, and put them back on the network when you are finished. Working directly off the network is often unreliable with large files. If your institute has a Windows file server, it could be a Windows/Linux thing, not sure, but it happens here as well sometimes.