The answer is probably yes, if you want to control stuff like focus and zoom. Leica uses an ascii based protocol via virtual serial port for this, and they have apparently not changed that protocol for years. I have a M205 available so I can in theory test this, but I am using that lab rarely so I do not know when I would get around to do it.
But for image capture, the answer is most likely no. Only very old cameras using the FireWire protocol are supported by MicroManager. If anyone has got MicroManager to communicate with recent USB3 Leica cameras I would be very interested in this.