The Neuroscience and Pain Research Unit (NPRU) has recently established a state-of-the-art, open access, optical microscopy facility, and now that image acquisition workflows are well established, the team has ambitious goals to also provide image analysis support. To that end, the Lab Operations line, within the NPRU, is adding a Computational Scientist to their preclinical optical microscopy team to focus on image analysis workflows supporting preclinical drug discovery programs. This Computational Scientist will be an integral member of the Lab Operations team, which broadly supports the NPRU portfolio of programs at various stages across all the disease areas of interest. The primary goal will be to enable project teams to accurately and efficiently quantitate pre-clinical microscopy data to drive robust decisions around target mechanisms and validation, compound effects, biomarkers and assay development. In this position, the successful candidate will work within a large matrix environment, collaborating across multiple groups including discovery biology, preclinical imaging, research statistics, and informatics. Responsibilities
Collaborate with scientists, including Neurodegeneration, Neuroinflammation and Psychiatry project teams to analyze and present results of the experiments employing various optical microscopy and video imaging modalities
Implement and apply innovative image analysis methods and develop algorithms to analyze complex, multi-dimensional images to help drive data-driven drug discovery and development decisions
Work with scientists to understand the biology and improve existing or derive new endpoints, utilize prior information and develop ‘fit-for-purpose’ approaches.
For more information, visit the Pfizer job description