Cellular Imaging Analyst (Senior Scientist) in Sweden

From our friends at AstraZeneca in Sweden:

[quote]Title: “Cellular Imaging Analyst (Senior Scientist) with Cellular Assay Development Skills”
AstraZeneca is a major international healthcare business engaged in the research, development, manufacture and marketing of prescription pharmaceuticals and the supply of healthcare services. But we’re more than one of the world’s leading pharmaceutical companies. At AstraZeneca, we’re proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.

The arena
Discovery Science is a global function within Innovative Medicines, IM, in AstraZeneca. Discovery Science supports innovative medicine project teams from multifunctional capability centers in Alderley Park, Boston and Mölndal. Discovery Sciences is mainly involved in early lead generation through the late Lead optimization stage of drug discovery. It is composed of several capabilities where Reagent and Assay Development (RAD) is one among several others such as Screening Sciences and Structure & Biophysics. This position will be placed in the RAD Department where we focus on delivering different types of reagents and assays for high impact into the drug development.

The role
This role applies to a analyst and technical specialist in the area of cell based imaging that have extensive experience of transforming cellular imaging data to quantified high quality results.

Tasks:
• To make data analysis and conversion of screening data to biological parameters and understanding
• To use and develop imaging-based assays for high content analysis of cells.
• To use and develop image analysis tools (using different imaging platforms, programs, script writing) for quantification of cells or sub-cellular components in a biologically and statistically relevant manner.
• To handle and process generated data and present results.
• To provide user support in high content imaging activities in the lab.
• To develop cellular assays that qualitatively and quantitatively assess functionality or expression patterns of genes or proteins.

Education:
You should have a Ph.D. degree or corresponding experience in a relevant scientific discipline with several years of relevant experience in of data analysis and conversion of screening data to biological parameters for quantifying and understanding of the results.

Experience and Competence:
• Extensive expertise in using and developing high content imaging microscopy methods/assays for label- or label-free characterization of cells.
• Extensive expertise in using and developing qualitative and quantitative image-based cellular assays and analysis methods suitable for drug screening.
• Extensive experience in culturing and functional characterization of cells
• Experience of drug discovery and cell deliverables in an industrial setting are advantages
• Expertise in cell-based assay design including knowledge of detection technologies, including spectroscopic (e.g. absorbance, fluorescence modalities), luminescent and label-free detection
• Practical understanding of assay optimisation, including statistical tools such as factorial experimental design, to enable generation of robust, reproducible and sensitive assays
• Understanding of data analysis and conversion of screening data to biological parameters

Other qualifications and skills:
In this role you should have understanding of how the drug discovery process functions within discovery. You should be able to understand how the different disciplines contribute to the discovery projects. You also should also be able to represent your discipline in a cross-disciplinary project team.

Preferred experience/requirements
In this role you should have understanding of how the drug discovery process functions within discovery. You should be able to understand how the different disciplines contribute to the discovery projects. You also should also be able to represent your discipline in a cross-disciplinary project team.

More information
For more information about the position please contact: Gabriella Brolén at +46 (0) 31 7766065 or Anna Collén at +46 31 7064341.
Welcome with your application no later than April 17th, 2014.[/quote]