Big size images could not be loaded into Orbit

Hi, I have a lot of H&E images to analyze, but I found the Orbit is hard to load the big size images (~ .tif file, ~ 300 Mb). Could anyone met the same problems or have any good suggestions? Thank you very much.

probably your tiff files don’t include pyramidal resolutions and/or are not tiled.
You can try to use e.g. imagemagick to convert them with e.g.

convert input.tif -define tiff:tile-geometry=512x512 -compress jpeg ptif:output.tif

the output.tif then should work with Orbit.

However, the preferred image format is original WSI formats, such as ndpi, svs,czi - maybe you have them in addition.