If I’m correct, it looks like you would like to do 3D segmentation and 3D neuron tracing on big data (hundreds of Gb). Is that right?
I fully understand that you do not want to invest in updates for partial solutions, and what Robert is offering is a very good option!
Please just keep in mind that the applications I listed above are challenging with big data. Sometimes, big data is already challenging for data handling, storage, processing, before thinking about any analysis really!
So depending on your needs, I think this is still a fair game to compare what you can have for free and what commercial solutions (Imaris, Aivia - I am part of DRVision company) could offer. Also because you might be interested in combining new tools (AI) to your 3D analysis, meaning getting latest tech, etc.
Here my message has no intention to force toward any direction, just to bring some more general info to your question. Hope this helps you to define your priorities and needs